Uveal colobomata and other anomalies in three generations of one family.

It is well recognized that typical colobomata of the uveal tract may show a strong hereditary tendency and that the transmission is usually dominant (Kelecom, I967). Associated with such colobomata there may be other ocular anomalies, such as microcornea (Srivastava, I96I; Batra and Paul, I967), microphthalmos (Petrovic-Ducic, I959; Duggan and Hassard, I96I; Zeiter, i963), aniridia (Lewallen, I958; Menderes, I962), medullated nerve fibres (Roy, I 965), nystagmus (Lewallen, I 958; Monahan, Hill, and Venters, 1967), heterochromia of the iris (Ammann, Klein, and Johr, I964), persistence of primary vitreous (Fran§ois, Neetens, and Carpentier, I964), heterotopia of the macula (Bernhard, I898), or cataract (Yanoff, Frayer, and Scheie, I963). Only rarely, however, have systemic abnormalities been reported (Duggan and Hassard, I96I; Ammann and others, I964; Zolog, I966; Zaikova and Bulatovskaya, I968). In this communication a family is presented with a high incidence of uveal colobomata in three generations, and in addition other anomalies, both ocular and systemic (Figure).